Tender For The Supply And Installation Of A Flash SARRP - University Of Birmingham

The University of Birmingham invites tenders for supply of a in-vivo radiation research platform (SARRP) capable of delivering X-ray irradiation at both conventional (~2-5 Gy/min) and ultra-high dose rates (FLASH; >40 Gy/sec). The system is required for both cultured cells (e.g. immortalised cell lines, primary cell cultures, 3D spheroids/organoids) as well as in-vivo models. The system will be used in scientific research to explore the biological impact of X-ray irradiation delivered at FLASH dose rates, particularly in terms of cell survival, growth of tumors, and impact on critical cellular structures such as DNA. This research spanning cancer, molecular and cellular biology aims to contribute to our further understanding of FLASH radiation, and to move this towards the clinic for the benefit of cancer patients treated with radiotherapy.

The system must be capable of delivering X-ray irradiation at FLASH dose rates (>40 Gy/sec) and be integrated within a shielded cabinet that is safe to use. Accurate and real-time dosimetry is very important. The system should have a stage which is manoeuvrable in three directions (X, Y and Z) plus a user-friendly and computer interface for precise cell positioning, but also come complete with a CCD camera for sample focusing and real-time monitoring. Continuing support in the maintenance and accuracy of dose delivery of the equipment is essential.

Please refer to Appendix A for full specification of requirements via www.in-tendhost.co.uk/universityofbirmingh… ↗