Fluorescence-detected Taylor Dispersion Analyser

The FidaNeo system provides capability for analysing biomolecular interactions directly in solution using proprietary FIDA technology, enabling measurement of binding affinity and molecular size changes in complex matrices such as serum or lipid nanodisc systems.

No instruments other than the Fida Neo could be identified that are capable of making the required measurements. No other instrument researched was capable of measuring the sub-nanometer size changes associated with protein conformational change (e.g. upon a drug binding to its target protein), nor did any other instrument researched provide the complementary readouts of fluorescence intensity required for quantifying particle concentration, quantifying fluorescent labelling efficiency, and measuring fluorescence quenching) and fluorescence ratiometric emission monitoring (required for measuring protein-drug binding).