202526 5355 - Optical Tweezers-Fluorescence Microscope

This procurement is being undertaken via a single-source route due to the unique

technical capabilities of the C-Trap® Dymo 400 and the exclusive rights held by its

manufacturer, LUMICKS B.V. the unique elements of this are:

• Multi-trap continuous-wave optical tweezers,
• Multi-colour confocal fluorescence microscopy, and
• Multi-channel laminar flow microfluidics.

These technologies are protected by several granted patents, including: US9952421,

EP3256254B1 (optical traps), US9766180, EP3004848B1 (fluorescence imaging),

S11156513B2 (optical force measurement) and EP3737756B1 (DNA supercoiling).

No other commercially available instrument can provide simultaneous, correlated forcedistance-fluorescence measurements with the required resolution and sensitivity.

Key performance features exclusive to the C-Trap include:

• Force resolution 0.1 pN and drift stability 0.3 pN over 2 minutes
• Confocal localisation precision 15 nm
• Real-time imaging of single molecules under physiological flow conditions
• Escape force 1000 pN, allowing for broad biological applicability
• Integrated hardware/software for fast setup and automated experimental workflows.

Additionally, the system includes a complete service and application support package,

exclusive training kits, and proprietary components that are not available from any other

provider