Supply, Delivery, Installation, Commissioning of Oligonucleotide Synthesis and Processing Equipment

Continuous Manufacturing and Crystallisation centre (CMAC) have a list of capital equipment that they are looking to purchase as part of the delivery of the CMAC Data Lab- Digital Medicine Manufacturing Research Accelerator project This equipment will be used primarily by and for CMAC, goods will be housed on site in CMAC. Specific areas of focus include peptide and oligonucleotide chemistry aimed at developing new treatment modalities for diseases of societal need. This proposal aims to acquire 2 multi-channel automated oligonucleotide synthesisers covering medium through put to high through put approaches. This system will enable the parallel production of DNA, LNA, RNA, 2' RNA modified oligonucleotides and conjugate derivatives using solid phase phosphonamidite chemistry. The systems will provide flexibility in terms of scale, low throughput, and high throughput parallel synthesis, allowing the synthesis of mixed backbones for methodology development purposes or quick access to multiple analogues in one run.