Extension of agreement for the management of an informatics platform which allows access to UK Biobank data

UKB currently hosts a cloud-based Research Analysis Platform which makes UKB data accessible to registered researchers within designated areas of the Research Analysis Platform, such that they can conduct their approved research project. The current Research Analysis Platform was procured by UKB in 2020. It was developed by DNAnexus, in collaboration with, and cloud infrastructure provided by, Amazon Web Services. At the end of Q2 2024 UKB adopted a Research Analysis Platform by default approach (with very limited exemptions), such that all UKB researchers were obliged to conduct their research on the Research Analysis Platform. The rationale behind this change is that the health record linkage data - both secondary and in due course primary - is now only permissible through a cloud-based environment (within the EEA). This significantly raised the level of adoption and usage of the Research Analysis Platform and required substantive improvements in functionality and scale to the Research Analysis Platform. As a consequence, the volume of researchers accessing the Research Analysis Platform has increased very significantly since it was first launched by UKB, with the number of researchers accessing data via the platform increasing from less than 50 in February 2021 to circa 16,500 in 2025.

UKB has extended its contract with DNAnexus for the ongoing management and support of the Research Analysis Platform for a period of two years to allow UKB to progress discrete but linked competitive procurement exercises in relation to the implementation of a secure data environment strategy which encompasses:

(i) the development of an Output Checking System (OCS) to improve the functionality and security of the UKB data and to facilitate the necessary certification by the Department of Health and Social Care (DHSC) and National Health Service (NHS) for the purposes of facilitating access to linked health record data and in particular the provision of the future primary care data;

(ii) the provision of cloud infrastructure for the storage and handling of growing volumes of UKB data and support proposed enhancements to the new Research Analysis Platform (see below); and

(iii) the development of a new Research Analysis Platform to provide a stable platform for research activities taking account of technology advancements over the past 5/6 years and incorporate new datasets to be accessed by researchers and make improvements to meta data storage and researcher tools.

On 23 April 2025, UKB issued Preliminary Market Engagement Notices in respect of the proposed procurements for the Output Checking System, cloud infrastructure and the new Research Analysis Platform. These Preliminary Market Engagement Notices were updated on 10 December 2025. These noted the inter-related nature of the three procurements and the intention to carry out the procurements for the Output Checking System and cloud infrastructure in advance of (and in order to inform) the procurement for the development of the new cloud infrastructure and Research Analysis Platform. As such, UKB intends to conduct the procurement of the Output Checking System first, in the first half of 2026, followed (in the second half of 2026 or early 2027) by the procurement of cloud infrastructure services that will apply once the new Research Analysis Platform is in operation and finally the conduct of the procurement for the new Research Analysis Platform in 2027. UKB intends to undertake preliminary market engagement in relation to the cloud infrastructure (to understand how storage capacity and compute optimisation can enhance the functionality and security of UKB's data) and in relation to the new Research Analysis Platform (to understand the needs of its researchers and the solutions which may be available on the market) before launch of the respective procurement exercises. This strategy and sequencing of the procurement exercises will facilitate a smooth transition - for UKB's many thousands of researchers - to an enhanced secure environment for the access and use of the critical UKB data and research projects.

The need for the Output Checking System was only made explicit in 2024 when the DHSC and NHS communicated the need for UKB to have certification in order to continue to receive and make available linked health record data and to be able to incorporate primary care data into UKB datasets. It is necessary and appropriate for the procurement exercises for both the Output Checking System and for the cloud infrastructure which will host the data once the new platform is established to be completed before preliminary market engagement can take place with suppliers and users regarding the requirements and strategic approach to the new Research Analysis Platform. The Output Checking System and cloud infrastructure procurement exercises need to be completed before the competitive procurement exercise for the development of the new platform, on the basis that the outputs and associated infrastructure will inform the technology solution for the new platform. The Output Checking System will be delivered first to meet both UKB and government need to increase the security of data and subsequently allow for new datasets to be accessed securely by researchers. The delivery of the OCS will also allow UKB to further develop data storage and usage requirements that will inform the cloud infrastructure procurement as well as the future Research Analysis Platform. In light of the above, to facilitate the procurement of the new platform and ensure an orderly transition to that new platform, an extension to the contract with DNAnexus was required. There is no practical prospect of another contractor operating the current Research Analysis Platform due to the proprietary DNAnexus intellectual property rights in the platform software and UKB's licence to such rights only being available during the life of the DNAnexus contract.

UKB considered that the extension to the …